RESORBABLE CHITOSAN HYDROGEL

NeuroShield’s chitosan hydrogel structure supports and protects the underlying nerve structure during soft tissue healing. Over time, the chitosan membrane naturally resorbs, degrading into compounds that may be beneficial for nerve regeneration.1-3

SURGEON-FRIENDLY

Along with the benefits of chitosan, NeuroShield offers the following handling characteristics based on its hydrogel structure:

> Transparent for easier membrane placement and repair visualization

> Soft, pliable and conforms to tissue

> Easy to suture, yet resists suture pull out

> One size wraps nerves up to 12 mm in diameter

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Helpful Resources

References

  1. 1. Carvalho CR, López-Cebral R, Silva-Correia J, Silva JM, Mano JF, Silva TH, Freier T, Reis RL, Oliveira JM. (2017). Investigation of cell adhesion in chitosan membranes for peripheral nerve regeneration. Materials Science and Engineering: C, 71, 1122–1134.

  2. 2. Wang Y, Zhao Y, Sun C, Hu W, Zhao J, Li G, Zhang L, Liu M, Liu Y, Ding F, Yang Y, Gu X. (2016). Chitosan degradation products promote nerve regeneration by stimulating schwann cell proliferation via miR-27a/FOXO1 axis. Molecular Neurobiology, 53, 28-39.

  3. 3. Zhao Y, Wang Y, Gong J, Yang L, Niu C, Ni X, Wang Y, Peng S, Gu X, Sun C, Yang Y. (2017). Chitosan degradation products facilitate peripheral nerve regeneration by improving macrophage constructed microenvironments. Biomaterials, 134, 64–77.